This magisterial book compiles research and review work on several topics such as grape varieties, pests, biotechnology, winemaking, emerging non-thermal technologies, wine stabilization, off-flavors, and even big data applications. The chapters have been authored by key researchers from nine countries and three continents. Grape and Wines is divided into three sections: “Grape Production and Plant Management,” “Fermentation and Microbiology,” and “Enology and Stabilization.” The first section includes chapters on pest control and pesticide management with an integrative perspective from plant to wine. The use of copper in vineyards is also reviewed along with detailed measures to reduce the use of this antifungal product. The use of big data and artificial intelligence is also analyzed in a specific chapter together with their application in grape production and winemaking. The peculiarities of varieties in Romania and Crimean Peninsula are also considered and, lastly, the impact of table grape production is also included.